Positive feedback, stochasticity and genetic competence
نویسندگان
چکیده
منابع مشابه
Positive feedback, stochasticity and genetic competence.
A single gene, regulating its own expression via a positive feedback loop, constitutes a common motif in gene regulatory networks and signalling cascades. Recent experiments on the development of competence in the bacterial population B. subtilis show that the autoregulatory genetic module by itself can give rise to two types of cellular states. The states correspond to the low and high express...
متن کاملReconciling competence and transcriptional hierarchies with stochasticity in retinal lineages☆
Recent advances suggest that there is a stochastic contribution to the proliferation and fate choice of retinal progenitors. How does this stochasticity fit with the progression of temporal competence and the transcriptional hierarchies that also influence cell division and cell fate in the developing retina? Where may stochasticity arise in the system and how do we make progress in this field ...
متن کاملModeling genetic switches with positive feedback loops.
In this paper, we develop a new methodology to design synthetic genetic switch networks with multiple genes and time delays, by using monotone dynamical systems. We show that the networks with only positive feedback loops have no stable oscillation but stable equilibria whose stability is independent of the time delays. In other words, such systems have ideal properties for switch networks and ...
متن کاملSubtle interplay of stochasticity and deterministic dynamics pervades an evolutionary plausible genetic circuit for Bacillus subtilis competence.
Here we study the interplay of stochastic and deterministic dynamics in an evolutionary plausible candidate core genetic circuit for Bacillus subtilis competence. We find that high noise would not necessarily be detrimental to the circuit's ability to deliver the phenotype, due to an unexpected built-in robustness that we further investigate. Also, we find that seemingly subtle deterministic dy...
متن کاملSkill Refinement through Competence Feedback
Learning is generally performed in two stages, knowledge acquisition and skill refinement. Developments within machine learning have tended to concentrate on knowledge acquisition as opposed to skill refinement. In this paper we develop mechanisms for skill refinement within the context of lazy learning by incorporating competence feedback into the exemplar base. The extent of competence feedba...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Physical Biology
سال: 2007
ISSN: 1478-3975
DOI: 10.1088/1478-3975/4/1/004